Simultaneous multiple peptide synthesis : Comparison of T - bags and cotton

The methodology of SPPS has evolved over recent years into several approaches of SMPS. Many techniques of this type have been reported [1]. The increasing interest in cntton [2] as support for SPPS led us to perform a detailed comparison of the peptide synthesis on this carrier with one of the alternative multiple peptide synthesis approaches. We selected the combination of MeBHA resin and T-bags of Houghten [3].